Catechin in Gambir Extract (Uncaria Gambir. Roxb) with a Protective Effect Against Inflammation and Hematological Alterations in Wistar Rats
Keywords:
Catechin, uncaria gambir, inflammatory, antioxidant, superoxide dismutaseAbstract
This study is to investigate the effects of catechins from Uncaria gambir extract, which has anti-inflammatory and antioxidant activities in Wistar male rats with peroral administration. Two weeks before the intervention, 24 mice were exposed to cigarette smoke for 3 hours/day, and then the mice were randomly divided into 4 groups, namely the control group (given aquadest), the dose group 45 mg/kg, 90 mg/kg and the group 180 mg/kg. Gambir extract is given the extract daily for 14 days, then blood samples are taken before and after the period of drug administration. The result was a significant increase in hemoglobin, hematocrit, MCV, and MCHC in the dose group of 180 mg/kg and increased leukocytes seen in all intervention groups. Decreased CRP values and elevated levels of superoxide dismutase (SOD) in the blood also saw significant differences before and after the intervention. This indicates a high anti-inflammatory and antioxidant activity of gambir, which will indirectly help prevent and inhibit inflammation in the body.
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